Phyto Therapeutic Treatment of Radiation-Induced Typical Morphological Changes of Small Intestine

Authors

  • S.L. Kalmakhelidze Tbilisi State Medical University, Department of Medical Physics and Biophysics ; Ivane Beritashvili Center of Experimental Biomedicine, Laboratory of Neurotoxicology
  • M.E. Gogebashvili Ivane Beritashvili Center of Experimental Biomedicine, Laboratory of Radiation Safety Problems
  • N.I. Ivanishvili Ivane Beritashvili Center of Experimental Biomedicine, Laboratory of Radiation Safety Problems
  • T.V. Sanikidze Tbilisi State Medical University, Department of Medical Physics and Biophysics ; Ivane Beritashvili Center of Experimental Biomedicine, Laboratory of Radiation Safety Problems
  • D.P. Museridze Ivane Beritashvili Center of Experimental Biomedicine, Laboratory of Neurotoxicology
  • G.L. Ormotsadze Tbilisi State Medical University, Department of Medical Physics and Biophysics ; Ivane Beritashvili Center of Experimental Biomedicine, Laboratory of Radiation Safety Problems

DOI:

https://doi.org/10.48614/rrs120213307

Keywords:

Gamma-Radiation, Small Intestine, Pectin Polysacarydes, Lemna minor L

Abstract

This study aims to identify the morphological changes in the small intestine after exposure to gamma irradiation (5Gy) and reduce the negative impact of irradiation with. Radiationinduced morphological changes of jejunum are thickening and shortening of intestinal microvilli and epithelial shedding. The villi are broken or dissolved to varying degrees, with a loose arrangement between the intestinal villus.The duckweed -Lemna minor has anti-inflammatory and antibacterial activity that reduces the negative impact of gamma irradiation on small intestines. Intake of Lemnan in the early post-irradiation period has a great significanceintheregenerative process of small intestine mucosa and increased survival rate of irradiated animals. Phytotherapeutic substance - Lemna minor. The active component of the duckweed is pectin polysaccharide - Lemnan, which increases the barrier-immune function of the small intestineThe results of the study indicate that Phytotherapeutic treatment on early post-radiation period reduces acutedelayed irradiation effects resulting in increased survival rate of irradiated animals.

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Published

2021-12-20

How to Cite

Kalmakhelidze, S., Gogebashvili, M., Ivanishvili, N., Sanikidze, T., Museridze, D., & Ormotsadze, G. (2021). Phyto Therapeutic Treatment of Radiation-Induced Typical Morphological Changes of Small Intestine. Radiobiology and Radiation Safety, 1(2), 87–92. https://doi.org/10.48614/rrs120213307